Cat: AB-1009
IL17A-Ab2, hIgG1, HEK293 Cells,others: Product Information
Monoclonal anti-human interleukin 17A (IL17A)
Detects human IL17A in ELISAs and Western blots.
Monoclonal Human IgG1
Recommended pairs in sandwich immunoassays (capture-detection):
AB-1008 & AB-1009
Protein A or G chromatography
Dissolved in sterile PBS buffer to a concentration of 0.5 mg/mL.
This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening.
Avoid repeated freeze-thaw cycles.
It is recommended that the protein be aliquoted for optimal storage.
12 months from date of receipt, -20 to -70 °C as supplied.
Shipping with dry ice.
> 95%, determined by SDS-PAGE
<0.010 EU per 1 ug of the protein by the LAL method
This product is sold for research or further manufacturing use only. Standard Laboratory Practices should be followed when handling this material.
IL17A-Ab2, hIgG1, HEK293 Cells,others: Product Information
IL17A-Ab2, hIgG1, HEK293 Cells,others: Product Information
IL17A-Ab2, hIgG1, HEK293 Cells,others: Product Information
Interleukin-17A (IL-17A), also known as CTLA-8, is a 15-20 kDa glycosylated cytokine that plays an important role in anti-microbial and chronic inflammation. The six IL-17 cytokines (IL-17A-F) are encoded by separate genes but adopt a conserved cystine knot fold (1, 2). Mature human IL-17A shares 60% amino acid sequence identity with mouse and rat IL-17A (3, 4). IL-17A is secreted by Th17 cells, gamma /δ T cells, iNKT cells, NK cells,LTi cells, neutrophils, and intestinal Paneth cells (2). It forms disulfide-linked homodimers as well as disulfide-linked heterodimers with IL-17F (5, 6).
IL-17A exerts its effects through the transmembrane IL-17RA in complex with IL-17RC or IL-17RD (7, 8). Both IL-17RA and IL-17RC are required for responsiveness to heterodimeric IL-17A/F (7). IL-17A promotes protective mucosal and epidermal inflammation in response to microbial infection (9-12). It induces chemokine production, neutrophil influx, and the production of antibacterial peptides (9-11). IL-17A/F likewise induces neutrophil migration, but IL-17F does not (11). IL-17A additionally enhances the production of inflammatory mediators by rheumatoid synovial fibroblasts and contributes to TNF-alpha induced shock (4, 13). In contrast, it can protect against the progression of colitis by limiting chronic inflammation (12). IL-17A has been shown to exert either tumorigenic or anti-tumor effects (14, 15).
1. Gaffen, S.L. (2009) Nat. Rev. Immunol. 9:556.
2. Cua, D.J. and C.M. Tato (2010) Nat. Rev. Immunol. 10:479.
3.Yao, Z. et al. (1995) J. Immunol. 155:5483.
4. Fossiez, F. et al. (1996) J. Exp. Med. 183:2593.
5. Chang, S.H. and C. Dong (2007) Cell Res. 17:435.
6. Wright, J.F. et al. (2007) J. Biol. Chem. 282:13447.
7. Wright, J.F. et al. (2008) J. Immunol. 181:2799.
8. Rong, Z. et al. (2009) Cell Res. 19:208.
9. Cho, J.S. et al. (2010) J. Clin. Invest. 120:1762.
10. Liang, S.C. et al. (2006) J. Exp. Med. 203:2271.
11. Liang, S.C. et al. (2007) J. Immunol. 179:7791.
12. O’Connor Jr., W. et al. (2009) Nat. Immunol. 10:603.
13. Takahashi, N. et al. (2008) J. Exp. Med. 205:1755.
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