Cat: HF-4004
PLA2R1, Human, HEK293 Cells,Tag Free: Product Information
> 95%, determined by SDS-PAGE
<0.010 EU per 1 ug of the protein by the LAL method.
Q13018
Human embryonic kidney cell, HEK293-derived human PLA2R1 protein
Glu21-Gly1393
159.5 kDa
Solution protein
Dissolved in sterile PBS buffer to a concentration of 1.0 mg/mL.
This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening.
Avoid repeated freeze-thaw cycles.
It is recommended that the protein be aliquoted for optimal storage.
12 months from date of receipt, -20 to -70 °C as supplied.
Shipping with dry ice.
PLA2R1, Human, HEK293 Cells,Tag Free: Product Information
4 ug/lane protein was resolved with SDS-PAGE under non-reducing (NR) and reducing (R) conditions and visualized by CoomassieBlue staining.
PLA2R1, Human, HEK293 Cells,Tag Free: Product Information
Secretory phospholipase A2 receptor, C-type lectin domain family 13 member C, PLA2R1, CLEC13C
PLA2R1, Human, HEK293 Cells,Tag Free: Product Information
PLA2R1 (phospholipase A2 receptor 1) also called muscle (M-) type PLA2R or secretory (s)PLA2R is a 180-200 kDa type I transmembrane glycoprotein that is a member of subgroup VI of the C-type lectin superfamily (1-3). The 1487 amino acid (aa) mouse PLA2R1 contains a 26 aa signal sequence, a 1370 aa ECD, a 21 aa transmembrane sequence, and a 70 aa cytoplasmic domain with an endocytosis motif. The ECD contains one ricin B-type lectin domain (aa 42-165), a fibronectin type II region (aa 176-224), and eight C-type lectin carbohydrate recognition domains (CRDs, aa 241-1377) (1-3). CRDs 3-5 are the major PLA2 binding site (1, 3). The mouse PLA2R1 ECD shares 75% and 86% aa identity with human and rat PLA2R1, respectively. One isoform shows a 35 aa N-terminal extension, and a potentially secreted isoform contains a 10 aa substitution for aa 680-1487 (4). Matrix metalloproteinases can generate a 180 kDa soluble inhibitory form in mouse serum that retains PLA2 binding activity (3, 5). Mouse PLA2R1 is widely expressed, including on type II alveolar cells, neutrophils and mast cells, and binds mouse secretory PLA2s IB, IIA, IIE, IIF and X, and snake venom PLAs (1-3, 5-7). Among mammals, PLA2R1 ligand recognition is mainly species-specific (3). PLA2R1 can be anti-inflammatory by inhibiting PLA2-induced release lipid mediators such as arachadonic acid (5 7, 8）.
1. Higashino, K-I. et al. (1994) Eur. J. Biochem. 225:375.
2. Lambeau, G. et al. (1994) J. Biol. Chem. 269:1575.
3. Hanasaki, K. (2004) Biol. Pharm. Bull. 27:1165.
4. SwissProt Accession Q62028.
5. Higashino, K-I. et al. (2002) J. Biol. Chem. 277:13583.
6. Rouault, M. et al. (2007) Biochemistry 46:1647.
7. Hanasaki, K. et al. (1997) Biol. Chem. 272:32792.
8. Ancian, P. et al. (1995) Biochemistry 34:13146.
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